The first inter-state numbering for the Roosevelt Highway was in , where the was established in 1922. followed the auto trail from Portland northwest to , where it continued to Burlington via . Many of the states along the route also assigned numbers to the highway; for instance, New York labeled their portion in 1924. The distributed its preliminary plan in 1925, in which a long section of the highway was labeled US 2, from west to . East of St. Ignace, instead of crossing to the like the Roosevelt Highway, the proposed Route 2 traveled north to the international border at . It reappeared at , following and then rejoining the auto trail between Burlington and Montpelier. US 2 and the Roosevelt Highway both connected Montpelier to , but the latter took a direct path along Route 18, while the former was assigned to to , where it proposed north to St. Johnsbury. There, where the Roosevelt Highway turned southeast to Portland, Route 2 continued east along to and to , then heading north on to end in .
By the time the U.S. Highway system was finalized in late 1926, one relatively minor change had been made to US 2; it was swapped with between Bangor and Houlton, Maine, placing US 2 along the entire portion of Route 15 east of St. Johnsbury. Several other major parts of the auto trail received numbers, most notably from Portland, Oregon east to , in eastern Washington, and in Michigan's Lower Peninsula. In the mid-1930s, much of New York's portion of the road became , and the part southeast of to Portland, Maine became , but by far the longest piece was that followed by US 2 between St. Ignace and Bonners Ferry. In 1946, US 2 was extended west of its original western terminus in Bonners Ferry in Idaho to Everett in Washington via Spokane along what was then Alternate US 10.
To sum up, these claims aren't yet been confirmed by the game developer. Thus, the gamers should keep their selves updates for the incoming updates for the game's release. Perhaps, they might expect The Last of Us 2 this year or maybe not.